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A01=Louise Serpell
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Misfolding of Amyloid-beta and tau in Alzheimers and Other Neurodegenerative Diseases

English

By (author): Louise Serpell

Misfolding of Amyloid-beta and tau in Alzheimers and Other Neurodegenerative Diseases describes historical discoveries of these two major proteins in Alzheimers disease and other neurodegenerative conditions. The book navigates through the importance of protein self-assembly, protein conformational change, and structural studies in understanding the positioning in the disease pathway. How these proteins are involved in the pathway to neuronal dysfunction, and the importance of understanding protein conformation and deposition for diagnosis are also highlighted. Although Alzheimers disease was discovered over 100 years ago, the role of protein misfolding in the pathology and cause of Alzheimers disease remains unclear. Amyloid-beta and Tau are both proteins well known for their involvement in Alzheimers disease. Both proteins misfolding and aggregate are deposited as cross-beta amyloid fibrils in the tissues. See more
Current price €122.54
Original price €128.99
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A01=Louise SerpellAge Group_UncategorizedAuthor_Louise Serpellautomatic-updateCategory1=Non-FictionCategory=MFGCategory=MJNCategory=PSAKCategory=PSANCOP=United KingdomDelivery_Pre-orderLanguage_EnglishPA=Not yet availablePrice_€100 and abovePS=Forthcomingsoftlaunch

Will deliver when available. Publication date 01 Jan 2025

Product Details
  • Dimensions: 151 x 229mm
  • Publication Date: 01 Jan 2025
  • Publisher: Elsevier Science & Technology
  • Publication City/Country: United Kingdom
  • Language: English
  • ISBN13: 9780323992688

About Louise Serpell

Professor Louise Serpell is a Professor of Biochemistry at the University of Sussex UK and a Director of Sussex Neuroscience. Her work focusses on protein self-assembly and misfolding at the heart of neurodegenerative diseases and amyloidosis. Louise Serpell has been conducting research to understand neurodegenerative diseases for over 25 years. She did her PhD in Oxford in 1992-1995 and then spent as a postdoc 2 years in Toronto Canada before returning to work in Cambridge where she set up an independent research group. She has been working at the University of Sussex for 18 years. She has an interest in protein self-assembly. A major aim of her research group is to understand the underlying causes of Alzheimers disease (AD). Her research group uses a highly multidisciplinary approach to investigate these questions incorporating a fibrous protein structure determination and neuroscience to examine the protein related mechanisms that lead to AD.

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