{"product_id":"computational-approaches-to-protein-dynamics","title":"Computational Approaches to Protein Dynamics","description":"\u003cp\u003e\u003cem\u003eThe Latest Developments on the Role of Dynamics in Protein Functions\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods\u003c\/strong\u003e presents modern biomolecular computational techniques that address protein flexibility\/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles.\u003c\/p\u003e\u003cp\u003eThe book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003cem\u003eIs there a quantitative relationship between enzymatic catalysis and protein dynamics?\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eWhich are the functionally relevant motions of proteins?\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eHow can structural properties and partner recognition mechanisms of IDPs be simulated?\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eHow can we speed up molecular dynamics? \u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eHow can we describe conformational ensembles by the synergistic effort of computations and experiments?\u003c\/em\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eWhile dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure–function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.\u003c\/p\u003e","brand":"Taylor \u0026 Francis Ltd","offers":[{"title":"Default Title","offer_id":54235355906392,"sku":"9781138198883","price":91.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0278\/1295\/4195\/files\/9781138198883_c2cf1cd8-2a08-4f5f-9980-2459c2f6bb6c.jpg?v=1779336943","url":"https:\/\/agendabookshop.com\/products\/computational-approaches-to-protein-dynamics","provider":"Agenda Bookshop","version":"1.0","type":"link"}