{"product_id":"enzyme-inhibition-in-drug-discovery-and-development","title":"Enzyme Inhibition in Drug Discovery and Development","description":"The science and applied approaches of enzyme inhibition in drug discovery and development  \u003cp\u003eOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.\u003c\/p\u003e \u003cp\u003eWith chapters written by over fifty leading experts in their fields, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the \"good\" inhibitions—desirable pharmacological effects—and \"bad\" inhibitions—drug–drug interactions and toxicity. The book discusses:\u003c\/p\u003e \u003cul\u003e\n\u003cli\u003e \u003cp\u003eThe drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eThe manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eThe inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway\u003c\/p\u003e \u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Product","offer_id":54222510096728,"sku":"9780470281741","price":241.74,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/agendabookshop.com\/products\/enzyme-inhibition-in-drug-discovery-and-development","provider":"Agenda Bookshop","version":"1.0","type":"link"}