{"product_id":"evaluation-of-drug-candidates-for-preclinical-development","title":"Evaluation of Drug Candidates for Preclinical Development","description":"\u003cp\u003eEmphasizes the integration of major areas of drug discovery and their importance in candidate evaluation\u003c\/p\u003e \u003cp\u003eIt is believed that selecting the \"right\" drug candidate for development is the key to success. In the last decade, pharmaceutical R\u0026amp;D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.\u003c\/p\u003e \u003cp\u003eEncompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:\u003c\/p\u003e \u003cul\u003e\n\u003cli\u003e \u003cp\u003eCover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eAddress developability issues that challenge pharma companies, moving beyond isolated experimental results\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eReveal connections between the key scientific areas that are critical for successful drug discovery and development\u003c\/p\u003e \u003c\/li\u003e\n\u003cli\u003e \u003cp\u003eInspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace\u003c\/p\u003e \u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eEvaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Product","offer_id":54222527234392,"sku":"9780470044919","price":123.99,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/agendabookshop.com\/products\/evaluation-of-drug-candidates-for-preclinical-development","provider":"Agenda Bookshop","version":"1.0","type":"link"}