{"product_id":"linker-strategies-in-solid-phase-organic-synthesis","title":"Linker Strategies in Solid-Phase Organic Synthesis","description":"Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis.  \u003cp\u003e\u003ci\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/i\u003e guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis.  Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include:\u003c\/p\u003e \u003cul\u003e\n\u003cli\u003ethe principles of solid phase organic synthesis\u003c\/li\u003e\n\u003cli\u003eelectrophile and nucleophile cleavable linker units\u003c\/li\u003e\n\u003cli\u003ecyclative cleavage as a solid phase strategy\u003c\/li\u003e\n\u003cli\u003ephotocleavable linker units\u003c\/li\u003e\n\u003cli\u003esafety-catch linker units\u003c\/li\u003e\n\u003cli\u003eenzyme cleavable linker units\u003c\/li\u003e\n\u003cli\u003eT1 and T2 –versatile triazene linker groups\u003c\/li\u003e\n\u003cli\u003ehydrazone linker units\u003c\/li\u003e\n\u003cli\u003ebenzotriazole linker units\u003c\/li\u003e\n\u003cli\u003ephosphorus linker units\u003c\/li\u003e\n\u003cli\u003esulfur linker units\u003c\/li\u003e\n\u003cli\u003eselenium and tellurium linker units\u003c\/li\u003e\n\u003cli\u003esulfur, oxygen and selenium linker units cleaved by radical processes\u003c\/li\u003e\n\u003cli\u003esilicon and germanium linker units\u003c\/li\u003e\n\u003cli\u003eboron and stannane linker units\u003c\/li\u003e\n\u003cli\u003ebismuth linker units\u003c\/li\u003e\n\u003cli\u003etransition metal carbonyl linker units\u003c\/li\u003e\n\u003cli\u003elinkers releasing olefins or cycloolefins by ring-closing metathesis\u003c\/li\u003e\n\u003cli\u003efluorous linker units\u003c\/li\u003e\n\u003cli\u003esolid-phase radiochemistry\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eThe book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLinker Strategies in Solid-Phase Organic Synthesis\u003c\/i\u003e is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":54233929843032,"sku":"9780470511169","price":223.14,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0278\/1295\/4195\/files\/9780470511169.jpg?v=1783033236","url":"https:\/\/agendabookshop.com\/products\/linker-strategies-in-solid-phase-organic-synthesis","provider":"Agenda Bookshop","version":"1.0","type":"link"}