{"product_id":"sample-preparation-in-lc-ms-bioanalysis","title":"Sample Preparation in LC-MS Bioanalysis","description":"\u003cp\u003e\u003cb\u003eRevised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFollowing in the footsteps of the previously published \u003ci\u003eHandbook of LC-MS Bioanalysis\u003c\/i\u003e, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. \u003c\/p\u003e \u003cp\u003eWhile advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research\/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include:\u003c\/p\u003e \u003cul\u003e\n\u003cli\u003eCurrent basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes)\u003c\/li\u003e\n\u003cli\u003eSample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor)\u003c\/li\u003e\n\u003cli\u003eCrucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates)\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eSample Preparation in LC-MS Bioanalysis\u003c\/i\u003e will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.\u003c\/p\u003e","brand":"John Wiley \u0026 Sons Inc","offers":[{"title":"Default Title","offer_id":54192698622296,"sku":null,"price":171.06,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0278\/1295\/4195\/files\/9781119274292_7109e9bf-65a2-471f-a43c-bf19c0bac436.jpg?v=1780382763","url":"https:\/\/agendabookshop.com\/products\/sample-preparation-in-lc-ms-bioanalysis","provider":"Agenda Bookshop","version":"1.0","type":"link"}