Abnormal Hemoglobins in Human Populations
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A01=Frank. B. Livingstone
A01=Jonathan Marks
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Abnormal Hemoglobins
American Negro Populations
anthropological genetics
Author_Frank. B. Livingstone
Author_Jonathan Marks
Category=JHB
Cent Thalassemia
Deficient Genotypes
Electrophoretic Variants
Endemic Malaria
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evolutionary genetics of hemoglobinopathies
evolutionary selection
Extremely High Frequencies
Falciparum Malaria
Fava Bean
G6PD
G6PD Deficiency
G6PD Enzyme Activity
Gene Frequency Change
genetic adaptation studies
Glucose-6 Phosphate Dehydrogenase
Hemoglobin Genotype
Hemoglobin Variants
Holoendemic Malaria
Kurdish Jews
Lower Parasite Rate
malaria resistance mechanisms
Normal Adult Hemoglobin
population genetics
Quartan Malaria
red blood cell disorders
Starch Gel Electrophoresis
Thalassemia Alleles
Thalassemia Gene
Product details
- ISBN 9781138518575
- Weight: 1070g
- Dimensions: 152 x 229mm
- Publication Date: 18 Sep 2018
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Hardback
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Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. This knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory. This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of different forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis. Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.
Frank. B. Livingstone, Jonathan Marks
