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A01=and Medicine
A01=Board on Environmental Studies and Toxicology
A01=Board on Life Sciences
A01=Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures
A01=Committee on Toxicology
A01=Division on Earth and Life Studies
A01=Engineering
A01=National Academies of Sciences
Age Group_Uncategorized
Age Group_Uncategorized
Author_and Medicine
Author_Board on Environmental Studies and Toxicology
Author_Board on Life Sciences
Author_Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures
Author_Committee on Toxicology
Author_Division on Earth and Life Studies
Author_Engineering
Author_National Academies of Sciences
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Category1=Non-Fiction
Category=JW
Category=RNP
COP=United States
Delivery_Delivery within 10-20 working days
Language_English
PA=To order
Price_€50 to €100
PS=Active
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Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense

The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.

Table of Contents
  • Front Matter
  • Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense
  • Summary
  • 1 Introduction
  • 2 Conceptual Framework and Prioritization Strategy
  • 3 Nontesting Approaches Relevant to Prediction of Acute Toxicity and Potency
  • 4 Assays for Predicting Acute Toxicity
  • 5 Integration and Decision-Making for Predictive Toxicology
  • 6 Lessons Learned and Next Steps
  • Appendix A: Biographical Information on the Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures
  • Appendix B: Available Data or Databases
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A01=and MedicineA01=Board on Environmental Studies and ToxicologyA01=Board on Life SciencesA01=Committee on Predictive-Toxicology Approaches for Military Assessments of Acute ExposuresA01=Committee on ToxicologyA01=Division on Earth and Life StudiesA01=EngineeringA01=National Academies of SciencesAge Group_UncategorizedAuthor_and MedicineAuthor_Board on Environmental Studies and ToxicologyAuthor_Board on Life SciencesAuthor_Committee on Predictive-Toxicology Approaches for Military Assessments of Acute ExposuresAuthor_Committee on ToxicologyAuthor_Division on Earth and Life StudiesAuthor_EngineeringAuthor_National Academies of Sciencesautomatic-updateCategory1=Non-FictionCategory=JWCategory=RNPCOP=United StatesDelivery_Delivery within 10-20 working daysLanguage_EnglishPA=To orderPrice_€50 to €100PS=Activesoftlaunch
Delivery/Collection within 10-20 working days
Product Details
  • Dimensions: 216 x 279mm
  • Publication Date: 01 Oct 2015
  • Publisher: National Academies Press
  • Publication City/Country: United States
  • Language: English
  • ISBN13: 9780309376662

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