Application of Toxicogenomics to Cross-Species Extrapolation
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A01=Board on Environmental Studies and Toxicology
A01=Board on Life Sciences
A01=Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
A01=Committee on Emerging Issues and Data on Environmental Contaminants
A01=Division on Earth and Life Studies
A01=National Research Council
Author_Board on Environmental Studies and Toxicology
Author_Board on Life Sciences
Author_Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
Author_Committee on Emerging Issues and Data on Environmental Contaminants
Author_Division on Earth and Life Studies
Author_National Research Council
Category=PS
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
Product details
- ISBN 9780309100847
- Dimensions: 152 x 229mm
- Publication Date: 24 Apr 2006
- Publisher: National Academies Press
- Publication City/Country: US
- Product Form: Paperback
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Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") andA metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics couldA enhance scientists' ability to make connections between data from experimental animal studies and human health.
Committee on Applications of Toxicogenomics to Cross-Species Extrapolation, Committee on Emerging Issues and Data on Environmental Contaminants, National Research Council
