Autophagy Of The Nervous System: Cellular Self-digestion In Neurons And Neurological Diseases
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Alzheimer's Disease
Autophagosomes
Autophagy
Axons
Category=PSF
Cell Death
Chaperone Proteins
Degradation
Disease
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Huntington's Disease
Lysosomes
Mitochondria
Neurodegeneration
Neurological Disorders
Neurons
Neuropathology
Parkinson's Disease
Protein Aggregation
Product details
- ISBN 9789814350440
- Publication Date: 10 Dec 2012
- Publisher: World Scientific Publishing Co Pte Ltd
- Publication City/Country: SG
- Product Form: Hardback
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What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.
