Biomolecular Crystallography

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A01=Bernhard Rupp
advanced structural bioinformatics
amino acid
applied probability theory
Author_Bernhard Rupp
basic error propagation
Bayes
Bayesian inference
biomolecular crystallography
Category=PNT
co-crystallization
conditional structure factor probability
conformational state
covariance
crystal geometry
crystal harvesting
crystalline state
crystallization kinetics
crystallization techniques
crystallographic methods for drug discovery
diffracted X-rays
diffraction
electron density
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experimental phasing
experimental phasing methods
heavy atom refinement
lattice
macromolecular structure analysis
macromolecular structure models
marker atom substructure
model building
model validation
molecular geometry
molecular replacement
molecular replacement techniques
molecular structure
non-crystallographic symmetry
normal distribution
nucleic acid
Patterson function
phase problem
phasing equation
photon counting
poisson distribution
probability distribution
protein
protein crystallization
protein crystallography
protein data bank
protein engineering
protein expression
protein purification
protein quarternary structure
protein solutions
protein structure
protein tertiary structure
reciprocal lattice
side chain interaction
space groups
structural biology
structure validation
structure validation protocols
symmetry
thermodynamics
unconditional structure factor probability
X-ray absorption
x-ray data processing
X-ray instrumentation
X-ray scattering

Product details

  • ISBN 9780815340812
  • Weight: 2500g
  • Dimensions: 210 x 280mm
  • Publication Date: 20 Oct 2009
  • Publisher: Taylor & Francis Inc
  • Publication City/Country: US
  • Product Form: Hardback
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Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.

Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

Bernhard Rupp is the CEO and founder of q.e.d. life science discoveries in California. Dr. Rupp established the protein drug target crystallography group at the University of California Lawrence Livermore National Laboratory in 1993 and expanded it into high throughput crystallization and structural genomics with focus on drug target structures and structure guided drug discovery. He was also a founding member of TB Structural Genomics Consortium. Dr. Rupp is a consultant for several US biotech ventures, universities, and instrument manufacturers. He is a member of the U.S. National Academy of Sciences Committee for Crystallography and NAS Keck Futures Initiatives panel. Dr. Rupp lectures regularly at NSF sponsored workshops on Biomolecular Crystallography and at the EMBO PEPC workshops on protein expression,

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