Brain Aging

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Adult Neurogenesis
age-related cognitive decline
Aged Female Rats
AMPA Receptor
AMPA Receptor Subunit
AMPA Subunit
animal models neuroscience
Area CA1
BK Channel
BN Rat
CA1 Pyramidal Neuron
CA1 Stratum Radiatum
Category=PDN
Category=PSAN
DNMS Task
Endothelium Derived Hyperpolarizing Factors
Entire ROI
eq_bestseller
eq_isMigrated=1
eq_nobargain
eq_non-fiction
eq_science
ER Ca
experimental gerontology research
Hippocampal CA1 Pyramidal Neuron
IGF-1 Axis
IGF-1 Deficiency
IGF-1 Level
MWM Performance
neurobiology of aging
neuroimaging techniques
Newborn Neurons
NMDA Receptor Activation
Pi Turnover
RNA Amplification
SK Channel
stereological analysis
synaptic plasticity
Unbiased Counting Frame

Product details

  • ISBN 9780849338182
  • Weight: 712g
  • Dimensions: 156 x 234mm
  • Publication Date: 19 Apr 2007
  • Publisher: Taylor & Francis Inc
  • Publication City/Country: US
  • Product Form: Hardback
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Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research.

Brain Aging: Models, Methods, and Mechanisms offers a selective overview of the research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain, this volume reviews critical studies of brain aging in new animal models, as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging.

Emphasizing normal brain aging rather than pathological degeneration, the text provides an understanding of fundamental age-related changes in the nervous system and hypothesis-driven research into their basis. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms, as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain.

Outlining relevant methods and techniques, this book provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this significant field.

Riddle, David R.