Computer Techniques in Preclinical and Clinical Drug Development
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A01=Robert C. Jackson
ADME Data
ADME Study
Antimetastatic Drug
Author_Robert C. Jackson
Bacterial Growth Inhibition
Blood Brain Barrier
Category=UGK
CD4 Cell
Cell Cycle Specific Agent
Cell Loss Factor
Cellular Automata
Cellular Pharmacokinetics
CLASSICAL PHARMACOKINETICS
clinical trial simulation
computational pharmacology
Dose D2
drug metabolism prediction
End Point
enzyme inhibition kinetics
eq_bestseller
eq_computing
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
Interspecies Scaling
Late HIV Infection
Median Effect Plots
Non-cross Resistant Drugs
Nonlinear Regression Fit
PB Pk Model
PBPK Model
PD Model
pharmacodynamic simulation
Pk Parameter
Plasma Concentration
predictive modeling in drug development
QSTR.
R2 Cells
toxicity modeling
Product details
- ISBN 9780849376825
- Weight: 630g
- Dimensions: 156 x 234mm
- Publication Date: 23 Jul 1996
- Publisher: Taylor & Francis Inc
- Publication City/Country: US
- Product Form: Hardback
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It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
Jackson, Robert C.
