Consanguinity, Inbreeding, and Genetic Drift in Italy
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A01=Antonio Moroni
A01=Gianna Zei
A01=L L Cavalli-sforza
Age disparity in sexual relationships
Agriculture (Chinese mythology)
Allele
Apennine Mountains
Apulia
Assortative mating
Aunt
Author_Antonio Moroni
Author_Gianna Zei
Author_L L Cavalli-sforza
Autocorrelation
Birth control
Birth rate
Calabria
Calculation
Category=PSAK
Coefficient of relationship
Consanguinity
Conscription
Cousin marriage
Demographic analysis
Demographic transition
Demography
Emilia-Romagna
Endogamy
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
Estimation
Etruscan civilization
Extended family
Founder effect
Friedreich's ataxia
Friuli-Venezia Giulia
Genealogical method
Genetic disorder
Genetic distance
Genetic diversity
Genetic drift
Genetic epidemiology
Genetic heterogeneity
Genetic linkage
Genetic testing
Genetic variance
Grandparent
Hemophagocytic lymphohistiocytosis
Heterozygote advantage
Inbreeding
Inbreeding depression
Internal migration
Italian Peninsula
Italians
La Spezia
Legitimacy (family law)
Liguria
Linkage disequilibrium
Monte Carlo method
Mortality rate
Mutation frequency
Mutation rate
Napoleonic Code
Northern Italy
Olivetti
Ostrogoths
Overdominance
Population genetics
Population size
Primogeniture
Province of Reggio Emilia
Reggio Emilia
Sicani
Southern Italy
Spouse
Surname
Trentino
Urbanization
World War II
Product details
- ISBN 9780691089928
- Weight: 340g
- Dimensions: 140 x 216mm
- Publication Date: 11 Apr 2004
- Publisher: Princeton University Press
- Publication City/Country: US
- Product Form: Paperback
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In 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student--a priest named Antonio Moroni--told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes the team's research for the first time. Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations.
The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters are also studied. Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding.
Luigi Luca Cavalli-Sforza is Professor of Genetics Emeritus at Stanford Medical School, and Member of the U.S. National Academy of Sciences. His books include "History and Geography of Human Genes" and "Genes, Peoples, and Languages". Antonio Moroni is Professor Emeritus of Ecology at the University of Parma (Italy) and member of the National Academy of Sciences (Academy of XL). Gianna Zei was Professor of Statistics and Biometry at the University of Pavia and directs the population genetics group of the CNR Institute of Molecular Genetics in Pavia.
