Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions
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A01=Giovanni Maga
A01=Giuseppe Villani
A01=Silvio Spadari
A01=Ulrich Hubscher
Author_Giovanni Maga
Author_Giuseppe Villani
Author_Silvio Spadari
Author_Ulrich Hubscher
Biotechnical Applications
Category=PSAK
Category=PSAX
Diseases
DNA Polymerases
DNA Repair
DNA Replication
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eq_non-fiction
eq_science
Product details
- ISBN 9789814299169
- Publication Date: 15 Apr 2010
- Publisher: World Scientific Publishing Co Pte Ltd
- Publication City/Country: SG
- Product Form: Hardback
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Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
