A01=Bruno Lemaitre
A01=Hannah Westlake
A01=Mark A Hanson
Author_Bruno Lemaitre
Author_Hannah Westlake
Author_Mark A Hanson
Category=PD
Drosophila
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
evolution
host-pathogens
Immunity
Innate immunity
Insects
Product details
- ISBN 9782889156467
- Weight: 513g
- Dimensions: 160 x 240mm
- Publication Date: 18 Mar 2025
- Publisher: Presses Polytechniques et Universitaires Romandes
- Publication City/Country: CH
- Product Form: Paperback
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Explores the genetics of Drosophila, or fruit flies, to further the study of immunity.
Animals possess efficient mechanisms for detecting and neutralizing infection. The application of Drosophila genetics, or the genetics of fruit flies, to the study of these mechanisms has generated insights into insect immunity and uncovered general principles of animal host defense. Although it is difficult to summarize the sheer number of studies published on Drosophila immunity in recent years, the Drosophila Immunity Handbook aims to provide an overview of recent research trends, challenges, and discoveries in immunity through the lens of Drosophila. This overview introduces scientists to the sophisticated fly immune system, highlights exciting recent findings in the field, and pushes new horizons of research by contextualizing existing research and discovering exciting avenues to explore.
These studies have shown that Drosophila have multiple defense “modules” that can be deployed in a coordinated response against distinct pathogens, using physical barriers such as epithelia and chitin, production of reactive oxygen species, antimicrobial factors, blood clotting, the melanization reaction, and complex cellular responses. Metabolic reprogramming also fuels the immune system and effectively combats pathogens, as do symbiont-mediated immunity, disease tolerance mechanisms, and behavioral immunity. The research presented here reveals broader roles of the immune system beyond infection, notably in disease pathologies such as neurodegeneration or cancer. This remarkable animal model has ultimately given us a better understanding of the multiple roles of the immune system at the organismal level.
Animals possess efficient mechanisms for detecting and neutralizing infection. The application of Drosophila genetics, or the genetics of fruit flies, to the study of these mechanisms has generated insights into insect immunity and uncovered general principles of animal host defense. Although it is difficult to summarize the sheer number of studies published on Drosophila immunity in recent years, the Drosophila Immunity Handbook aims to provide an overview of recent research trends, challenges, and discoveries in immunity through the lens of Drosophila. This overview introduces scientists to the sophisticated fly immune system, highlights exciting recent findings in the field, and pushes new horizons of research by contextualizing existing research and discovering exciting avenues to explore.
These studies have shown that Drosophila have multiple defense “modules” that can be deployed in a coordinated response against distinct pathogens, using physical barriers such as epithelia and chitin, production of reactive oxygen species, antimicrobial factors, blood clotting, the melanization reaction, and complex cellular responses. Metabolic reprogramming also fuels the immune system and effectively combats pathogens, as do symbiont-mediated immunity, disease tolerance mechanisms, and behavioral immunity. The research presented here reveals broader roles of the immune system beyond infection, notably in disease pathologies such as neurodegeneration or cancer. This remarkable animal model has ultimately given us a better understanding of the multiple roles of the immune system at the organismal level.
Hannah Westlake led an extensive reproducibility project and literature analysis in the field of Drosophila immunity at EPFL (Switzerland) with Bruno Lemaitre. Mark Hanson is principle investigator at the University of Exeter. Bruno Lemaitre is professor at the Ecole Polytechnique of Lausanne (Switzerland), and he has worked on the Drosophila immune response since the early 1990s. He has also published several books at EPFL Press on science and narcissism and the philosophy of Michael Polanyi.
