First Signals

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Abiogenesis
Amoeba
Archaea
Author_John Tyler Bonner
Auxin
Bacteria
Baldwin effect
Biochemistry
Biology
Caenorhabditis
Cancer cell
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Cell division
Cell signaling
Charles Darwin
Ciliate
Coevolution
Cope's rule
Cyanobacteria
Developmental biology
Dictyostelium
Digestive enzyme
Ecology
Embryo
Embryology
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Eusociality
Evolution
Evolutionary developmental biology
Fungus
Gamete
Gene
Genetic linkage
Germ plasm
Germline
Hans Driesch
Heterocyst
Hypha
Immortalised cell line
Lipid
Mary Jane West-Eberhard
Meiosis
Metabolism
Microbiological culture
Microorganism
Modern evolutionary synthesis
Mold
Molecular biology
Molecule
Morphogen
Morphogenesis
Multicellular organism
Natural selection
Nematode
Nutrient
Obligate anaerobe
Oomycete
Organism
Orthogenesis
Pattern formation
Phagocytosis
Phenotypic plasticity
Pheromone
Plant
Plasmodium
Protein
Regulation of gene expression
Reproductive success
Slime mold
Syncytium
Termite
Volvox
Zoospore

Product details

  • ISBN 9780691070384
  • Weight: 170g
  • Dimensions: 140 x 216mm
  • Publication Date: 23 Jan 2001
  • Publisher: Princeton University Press
  • Publication City/Country: US
  • Product Form: Paperback
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The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.
John Tyler Bonner is George M. Moffett Professor of Biology Ementus at Princeton University. His many books include Sixty Years in Biology. Essays on Evolution and Development, Life Cycles: Reflections of on Evolutionary Biologist. The Evolution of Complexity by Means of Natural Selection, and The Evolution of Culture in Animals (all Princeton).

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