Gap Junction Channels and Hemichannels
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advanced gap junction research techniques
Age Group_Uncategorized
Age Group_Uncategorized
Agustin D. Martinez
Alberto E. Pereda
Alessio Lissoni
Annular Gap Junction
ATP Release
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B01=Donglin Bai
B01=Juan C. Sáez
bioinformatics in cell biology
Bleach Region
Category1=Non-Fiction
Category=PSF
cell membrane communication
cell membranes
cell physiology
Cell signaling
Charles G. Fisher
Colin R. Green
Connexin Hemichannels
connexin protein analysis
COP=United States
Coreceptor CCR5
Courtney A. Veilleux
Cx38 Hemichannels
Cx43 Gap Junction Channels
David C. Spray
Delivery_Delivery within 10-20 working days
electrophysiology protocols
Eliseo A. Eugenin
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eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
fluorescent imaging methods
Fluorescent Protein Tagged
Form Gap Junction Plaques
Frap Data
Frap Experiment
Frap Technique
Gap Junction
Gap Junction Channels
Gap Junction Plaque
Gigaohm Seal
Guillermo A. Altenberg
intercellular signaling pathways
ion channels
Isaac E. Garcia
John A. Cameron
Jorge E. Contreras
Jose F. Ek Vitorin
Juan Manuel Valdez Capuccino
Karin R. Sipido
Language_English
Luc Leybaert
Maarten De Smet
Matthias M. Falk
Mauthner Cell
Mohamed Kreir
Nan Wang
Open Hemichannels
Oscar Jara
PA=Available
Pannexin Channels
Patch Clamp Amplifier
Patch Pipette
Paula Mujica
Price_€100 and above
PS=Active
Rachael M. Kells
Rachael M. Kells Andrews
Randy F. Stout
Ricardo Ceriani
Roger Cachope
Sandra A. Murray
Sebastian Curti
Slow Activation Kinetics
softlaunch
T. I. Shakespeare
Tail Currents
Tia J. Kowal
Tobacco Etch Virus Protease
Triton X100 Soluble Fractions
Yeri Kim
Product details
- ISBN 9781498738620
- Weight: 602g
- Dimensions: 156 x 234mm
- Publication Date: 18 Aug 2016
- Publisher: Taylor & Francis Inc
- Publication City/Country: US
- Product Form: Hardback
- Language: English
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Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.
Donglin Bai received his Ph.D. from University of Cambridge, U.K. (1994). He then moved to Canada and worked on neurotransmitter receptors (GABA, NMDA, AMPA, noradrenaline, angiotensin) in Loeb Research Institute (Ottawa), Department of Physiology (Toronto) and Samuel Lunenfeld Research Institute (Toronto) as a postdoctoral fellow. In 2002 he was recruited as an Assistant Professor at Department of Physiology and Pharmacology, the University of Western Ontario. He is currently a tenured Associate Professor in the same university. His current research interests are on the physiology of gap junction channels, including gap junction channel docking, single channel conductance and gating properties. He is also interested in revealing how gap junction gene mutants linking to human diseases (cardiac arrhythmias, hypomyelination, cataracts, deafness and skin diseases) and developing strategies of rescuing the mutants. He received grants support from the following Canadian funding agencies: CIHR, CRC, NSERC, HSFC and ERA.
Dr. Juan C. Sáez received his PhD in neuroscience from Albert Einstein College of Medicine (AECOM), New York, New York, in 1986. He stayed for one year as an instructor in the Department of Neuroscience of AECOM, and then, he became an assistant professor in the same department. In 1993, he joined the Physiology Department of the Pontificia Universidad Católica de Chile, Santiago, Chile, where he has been a professor since 2003. His current research interest is understanding the regulation and the function of connexin- and pannexin-based channels in different cell types, including the cells of the nervous system, the immune system, and the gastrointestinal system and, more recently, on skeletal muscles. He has also characterized biophysical features of the mentioned channels. Recently, he has also used protocols for identifying highly selective inhibitors of connexin hemichannels without an effect on gap junction channels and with potent anti-inflammatory activity to treat chronic diseases. He has been continuously funded through the National Institutes of Health and different foundations of the Chilean government.
