Genetics of Bacterial Polysaccharides
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Aeruginosa LPS
Arabinosyl Transferases
bacterial cell wall synthesis
Capsular Polysaccharide Structures
Capsular Polysaccharides
capsule
Capsule Expression
Capsule Genes
Capsule Locus
Capsule Production
carrier
Category=PSAK
Category=PSG
CF Isolate
Chain Biosynthesis
Cholerae O1
clusters
core
Core Oligosaccharides
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experimental genetics techniques
GC Strain
Gene Cluster
genetic analysis of bacterial polysaccharides
genetic regulation mechanisms
host immune evasion
Infection Threads
Inferred Amino Acid Sequence
lipid
lipopolysaccharide
locus
lps
LPS Core
microbial pathogenesis
Mycolic Acids
O-antigen Polymerase
oligosaccharide
Opa Proteins
Pe Ci
Pneumoniae Type
Rhamnosyl Transferase
symbiotic plant bacteria
synthesis
Vibrio Cholerae
Product details
- ISBN 9780849300219
- Weight: 500g
- Dimensions: 156 x 234mm
- Publication Date: 30 Apr 1999
- Publisher: Taylor & Francis Inc
- Publication City/Country: US
- Product Form: Hardback
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Bacterial surface or secreted polysaccharides are molecules that can function as barriers to protect bacterial cells against environmental stresses, as well as act as adhesins or recognition molecules. In some cases, these molecules are immunodominant antigens eliciting a vigorous immune response, while in other cases the expression of polysaccharides camouflages the bacteria from the immune system. Until recently, most studies on the enzymatic steps and regulation of these molecules were performed on the enteric gram negative bacteria Escherichia coli and Salmonella typhimurium. With the advent of modern bacterial genetics, techniques such as construction and characterization of polysaccharide mutants, cloning of genes and complementation of these mutations, and expression of polysaccharides in heterologous bacterial hosts has prompted investigations into the roles and functions of these molecules for many different bacteria.
Here, we present the genetic analysis of polysaccharides from a number of bacteria pathogenic to humans and one symbiotic with plants in hopes that similarities in the experimental approaches as well as finding s from such investigations may lead to a general understanding of polysaccharide synthesis and regulation in various bacteria.
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Joanna B. Goldberg, Ph.D., has been an Associate Professor in the Department of Microbiology at the University of Virginia Health Sciences Center since 1996. She received her B.A. in Biology with Distinction from Boston University in 1979 and her Ph.D. from the Department of Microbiology and Immunology at the University of California, Berkeley, in 1986. In 1989, Dr. Goldberg joined the faculty at the Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, as an instructor and then assistant professor. Her research has focused on bacterial pathogenesis with an emphasis on polysaccharides as virulence factors and vaccine candidates.
