Genomic Approaches for Cross-Species Extrapolation in Toxicology
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Assessment Endpoints
bioinformatics integration
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Chemical Exposures
Comparative Toxicogenomics
computational biology methods
Cross-species Extrapolation
Da Ph
DNA Damage
DNA Microarrays
DNA Repair
DNA Repair Gene
ecological
Ecological Risk
Ecological Risk Assessment
environmental genomics
Environmental Toxicology
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EST Library
expression
gene
Herring Gull
Measure DNA Damage
Metabolite Libraries
molecular toxicology
omics
Omics Approaches
Omics Data
Omics Technologies
Orthology Prediction
phenotypic
predictive toxicology modeling
proteomic analysis
Quantitative Structure Activity Relationships
rainbow
regulatory toxicology
risk
Risk Assessment
Surrogate Species
technologies
Toxic Moa
Zebra Finch
Product details
- ISBN 9781420043341
- Weight: 440g
- Dimensions: 156 x 234mm
- Publication Date: 13 Dec 2006
- Publisher: Taylor & Francis Inc
- Publication City/Country: US
- Product Form: Hardback
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The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from the experience of thirty-five scientists and professionals from diverse fields including environmental toxicology and chemistry, biomedical toxicology, molecular biology, genetics, physiology, bioinformatics, computer science, and statistics.
The book introduces genomic, transcriptomic, proteomic, and metabolomic technologies. It describes the advantages and challenges associated with these approaches compared to traditional methodologies, particularly from the perspective of cross-species extrapolation within human and environmental toxicology, and explores solutions that will facilitate the incorporation of these technologies into predictive toxicology. The book goes on to identify and prioritize species of animals that can serve as surrogates for environmental and human health in comparative toxicogenomic studies. The chapter authors elucidate similarities and differences among species, relate stressor-mediated responses to adverse outcomes, and extend this science into innovative approaches to risk assessment and regulatory decision-making.
William H. Benson, Richard T. Di Giulio
