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Growth Hormone Secretagogues in Clinical Practice

Barry B. Bercu | Richard F. Walker
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A01=Barry B. Bercu
A01=Richard F. Walker
Abu15
arcuate
Arcuate Neurons
Arcuate Nucleus
Author_Barry B. Bercu
Author_Richard F. Walker
Category=PSF
cells
deficiency
diagnostic tests for pituitary dysfunction
endocrinology research
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
GH Deficiency
GH Deficient Child
GH Level
GH Peak
GH Peak Response
GH Receptor
GH Release
GH Response
GH Secretion
GH Secretory Response
ghr
GHRP
GHS Receptor
Growth Hormone Secretagogues
Growth HormoneReleasing Hormone
hormone receptor signaling
Idiopathic Short Stature
IGF-1 Level
mathematical modeling in endocrinology
Neurosecretory Cells
nucleus
pediatric endocrine disorders
peptide analogs
pituitary
pituitary gland function
Pulsatile GH Secretion
Rat Anterior Pituitary Cells
Rat Pituitary Cells
release
releasing
response
secretion
Serum IGF-1
Stimulate GH Secretion

Product details

  • ISBN 9780367400484
  • Weight: 453g
  • Dimensions: 152 x 229mm
  • Publication Date: 27 Sep 2019
  • Publisher: Taylor & Francis Ltd
  • Publication City/Country: GB
  • Product Form: Paperback
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Description

Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds.
Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice

  • analyzes structural requirements for GH secretagogue efficacy
  • demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary
  • reports on the development of a simple screening system based on polyclonal antibodies
  • discusses laboratory synthesis of agonistic analogs intended for human and veterinary use
  • proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer
  • provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise
  • describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults
  • explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons
  • and much more!
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    About Barry B. Bercu | Richard F. Walker
    Bercu, Barry B.; Walker, Richard F.

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