Homology, Genes, and Evolutionary Innovation
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A01=Gunter P. Wagner
Amniote
Anatomy
Appendage
Author_Gunter P. Wagner
Biologist
Biology
Body plan
Category=PDA
Category=PSAJ
Cell signaling
Cell type
Cellular differentiation
Charles Darwin
Cis-regulatory element
Common descent
Comparative anatomy
Conserved sequence
Developmental biology
Drosophila
Ectoderm
Embryo
Enhancer (genetics)
Epidermis
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eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
Evolution
Evolutionary biology
Evolutionary developmental biology
Evolvability
Forelimb
Frog
Gene
Gene duplication
Gene expression
Gene family
Gene regulatory network
Genetic variation
Genotype
Homeobox
Homology (biology)
Hox gene
HOXA11
Inference
Insect
Larva
Limb development
Mammal
Mesenchyme
Molecular biology
Morphogenesis
Most recent common ancestor
Natural selection
Nucleic acid sequence
Nucleotide
Organism
Paleontology
Pattern formation
PAX6
Phenotype
Phylogenetics
Population genetics
Protein
Protein-protein interaction
Regulation of gene expression
Regulator gene
Serial homology
Signal transduction
Sonic hedgehog
Speciation
Taxon
Tetrapod
Transcription factor
Transposable element
Vertebrate
Zebrafish
Product details
- ISBN 9780691156460
- Weight: 794g
- Dimensions: 152 x 235mm
- Publication Date: 13 Apr 2014
- Publisher: Princeton University Press
- Publication City/Country: US
- Product Form: Hardback
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Homology--a similar trait shared by different species and derived from common ancestry, such as a seal's fin and a bird's wing--is one of the most fundamental yet challenging concepts in evolutionary biology. This groundbreaking book provides the first mechanistically based theory of what homology is and how it arises in evolution. Gunter Wagner, one of the preeminent researchers in the field, argues that homology, or character identity, can be explained through the historical continuity of character identity networks--that is, the gene regulatory networks that enable differential gene expression. He shows how character identity is independent of the form and function of the character itself because the same network can activate different effector genes and thus control the development of different shapes, sizes, and qualities of the character. Demonstrating how this theoretical model can provide a foundation for understanding the evolutionary origin of novel characters, Wagner applies it to the origin and evolution of specific systems, such as cell types; skin, hair, and feathers; limbs and digits; and flowers.
The first major synthesis of homology to be published in decades, Homology, Genes, and Evolutionary Innovation reveals how a mechanistically based theory can serve as a unifying concept for any branch of science concerned with the structure and development of organisms, and how it can help explain major transitions in evolution and broad patterns of biological diversity.
Gunter P. Wagner is the Alison Richard Professor of Ecology and Evolutionary Biology at Yale University and a pioneer of the field of evolutionary developmental biology. He is the editor of The Character Concept in Evolutionary Biology.
