How Proteins Work

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A01=Michael Williamson
A01=Mike Williamson
acetylation
actin
activated conformation
active site
affinity
allostery
alpha helix
amino acid
amyloid
aromatic amino acid
ATP Hydrolysis
ATP Synthase
Author_Michael Williamson
Author_Mike Williamson
autoinhibition
beta oxidation
beta sheet
biosynthesis
Brownian motion
CAP
catalysis
Category=PSB
cell movement
channeling
chemical bond
chloroplast
coenzyme
cofactor
colocation
computational biology
Conformational Selection
cooperativity
cyclic reaction
cytoskeleton
dephosphorylation
diffraction
diffusion
dimer
DNA
DNA Bind Protein
domain swapping
dynein
electron transport chain
electrostatic attraction
electrostatic force
electrostatic repulsion
elongation
energy
enthalpy
entropy
enzyme
enzyme complex
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
ER
evolution
exon shuffling
exosome
FAS
fatty acid synthase
flagella
functional motion
G Protein
gene duplication
gene sharing
genetics
globular protein
glycogen phosphorylase
glycosylation
GPCR
Hedgehog
hemoglobin
hinge bending
histidine kinase
hydrogen bond
hydrophobic interaction
in vivo
induced fit model
inhibition
integral membrane complex
interactome
intracmolucular binding
ion channel
isozyme
ITC
JAK
kinesin
kJ Mol-1
Leucine zipper
Lipoyl Domains
lock and key model
Macromolecular Crowding
mass sectrometry
Mat A2
max
membrane protein
metabolon
methylation
microtubule
mitochondria
mitosis
modification
module
molecular biology
molecular biophysics
molecular machine
molecular machines
molecular switch
motor protein
multidomain construction
multienzyme complex
muscle contraction
MWC Model
myc
myosin
Myosin Head
Myosin II
natively unstructured protein
NMR Spectrum
NMR Structure
nonribosomal peptide
Notch
oligomer
oligomerisation
oligomerization
operon
PDB File
PDH
peptide
phosphorylation
photosynthesis
pKa
Pol II
Pol Ii Complex
Pol III
polyketide synthase
primary structure
processivity
Proline Rich Sequences
protein binding
protein complex
protein conformation
protein domain
protein domain architecture
protein dynamics
protein expression
protein flexibility
protein interaction
protein misfolding
protein motion
protein purification
protein structural evolution in biology
protein structure
protein-protein interactions
Proteins Work
proteolysis
proteolytic cascade
proteomics
pump
quaternary structure
Raf
random coil
random walk
Ras
ratchet
receptor
repressor
RNA
RNAse PH
scaffold protein
SDS Page Gel
searching
secondary structure
SH2 Domain
SH3 Domain
signal sequence
signal transduction mechanisms
SPR
Stat
sticky arm
structural homology
structure motif
substrate
tertiary structure
thermodynamics
thermolysin
Tramp Complex
transition state
transport
transposable domain
triosephosphate isomerase
tryptophane synthase
tubulin
tyrosine kinase
van der walls force
vesicle

Product details

  • ISBN 9780815344469
  • Weight: 1360g
  • Dimensions: 210 x 280mm
  • Publication Date: 20 Jul 2011
  • Publisher: Taylor & Francis Inc
  • Publication City/Country: US
  • Product Form: Paperback
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How Proteins Work is an up-to-date and authoritative account of protein function in living systems, explained within the governing parameters of physics, chemistry, and evolution. This text will enable advanced undergraduate students in biochemistry and biophysics to understand the relationships among protein function, structure, and dynamics. It will also serve as a valuable resource for graduate students and researchers looking for a reference on the fundamentals underlying protein function.

By providing an integrated view of proteins at both a cellular and systemic level, this textbook shows how evolution drives proteins to adopt domain structures that combine to achieve biological outcomes. The association of proteins into dimers, molecular machines, and multi-enzymatic complexes enables them to achieve catalytic and functional efficiency.

Mike Williamson did his PhD and subsequent research at the University of Cambridge before moving to the lab of Nobel Laureate Kurt Wüthrich in Switzerland.  There he worked on the first NMR structure of a globular protein.  He is a professor of Biochemistry at the University of Sheffield.