Human Developmental Toxicants
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€80.99
A01=James L. Schardein
A01=Orest T. Macina
animal model research
Animal Studies
area
Author_James L. Schardein
Author_Orest T. Macina
Category=PSB
Category=PSC
CCCC.
chemical hazard evaluation
Developmental Toxicants
Developmental Toxicity
Developmental Toxicity Profile
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eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
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Fetal Body Weight
Fetal Growth Retardation
Fetal Hydantoin Syndrome
Fetal Weight
Human Developmental Toxicant
Hydrogen Bond Acceptor
hydrophilic
industrial toxicants
Inhibit DNA Polymerase
Intrauterine Growth Retardation
Labioscrotal Fusion
Large Hydrophobic Molecule
molecular structure analysis
National Library
OCC
parameter
pharmaceutical developmental toxicity studies
pharmaceutical toxicants
Pigtail Monkey
polar
pregnancy
Pregnancy Risk Category
prenatal exposure effects
properties
Reproductive Toxicant
RXR Agonist
Smile
solubility
structure-activity relationship models
surface
teratogenic risk assessment
topological
toxicity
toxicity data
toxicological mechanisms
West Germany
Product details
- ISBN 9780367403577
- Weight: 453g
- Dimensions: 178 x 254mm
- Publication Date: 23 Sep 2019
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Paperback
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Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.
This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. Accompanying downloadable resources summarize all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.
As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.
Schardein, James L.; Macina, Orest T.
