Ig Superfamily Molecules in the Nervous System
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A01=Peter Sonderegger
activity-dependent neural plasticity
Author_Peter Sonderegger
axon guidance pathways
Category=PSAN
Category=PSD
Category=PSF
cell adhesion proteins
CNS Axon
CNS Neuron
Commissural Axons
DRG Neuron
Eph Receptors
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Fa II
FNIII Repeat
Growth Cones
Homophilic Binding
Ig Domains
Ig Superfamily
IgSF CAMs
Mam Domain
molecular neuroscience research
Mouse L1
NCAM
NCAM Molecule
NCAM Polysialylation
neural development mechanisms
Neurite Outgrowth
neurogenesis signalling
Optic Nerve Transection
PDGF Receptor Family
PSA
Rat RGC
RGC Axon
Schwann Cells
synaptic plasticity regulation
Wlds Mice
Product details
- ISBN 9789057024115
- Weight: 930g
- Dimensions: 174 x 246mm
- Publication Date: 18 Jan 1999
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Hardback
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A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems.
This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
