Immunodeficient Rodents
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This volume is an indispensable reference on the nature of immune defects in rodents and the special techniques necessary to maintain and breed them. The authors describe 64 inbred, hybrid, and mutant strains of rodents, each with some immune defect; explain mechanisms for ensuring genetic purity; and provide a standardized nomenclature for different varieties. Subsequent sections summarize and provide references on the genetics, pathophysiology, husbandry, and reproduction of each of the various strains as well as sound advice on planning for the selection, transportation, housing, and maintenance of these animals.
Table of Contents- FRONT MATTER
- 1 INTRODUCTION
- 2 HEREDITARY IMMUNODEFICIENCIES
- 3 INDUCED IMMUNODEFICIENCIES
- 4 MAINTENANCE OF RODENTS REQUIRING ISOLATION
- 5 MATING SYSTEMS FOR MUTANTS
- 6 GENETIC MECHANISMS GOVERNING RESISTANCE OR SUSCEPTIBILITY . . .
- REFERENCES
- APPENDIX: HEMATOPOIETIC CELL-SURFACE ANTIGENS MENTIONED IN THE TEXT
- GLOSSARY
- INDEX
Committee on Immunologically Compromised Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council