Innovative DNA Array Technology Detection of Pharmaceuticals Reclaimed Water
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A01=S. W. Kullman
Author_S. W. Kullman
Category=PNF
Category=PSB
Category=PSE
contaminants
detection
DNA array
eq_bestseller
eq_isMigrated=1
eq_nobargain
eq_non-fiction
eq_science
pharmaceuticals
reclaimed water
Product details
- ISBN 9781843397373
- Dimensions: 156 x 234mm
- Publication Date: 30 Apr 2007
- Publisher: IWA Publishing
- Publication City/Country: GB
- Product Form: Paperback
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Numerous pharmaceutical substances and their metabolites have been identified in the aquatic environment. Due to their unique environmental fate and lack of appropriate biomonitoring techniques, the potential risk of these compounds to public and environmental health has largely been undetermined. Recent interest in quantifying pharmaceuticals in waste effluents and aquatic environments has identified the need to develop bioanalytical assays that will accurately reflect presence of these compounds.
The goal of this research was to investigate the use of DNA microarrays as a bioanalytical tool for analysis of pharmaceutical contamination in re-use waters. Results from this study suggest that prototypic pharmaceutical contaminants target molecular events associated with pharmaceutical-induced gene induction and repression in exposed organisms. Gene expression profiles are subsequently evaluated as a means to discern pharmaceutical exposure. When fully developed, this bioanalytical approach will provide an efficient and robust method for screening pharmaceutical contaminants in reuse and other water matrices.
The goal of this research was to investigate the use of DNA microarrays as a bioanalytical tool for analysis of pharmaceutical contamination in re-use waters. Results from this study suggest that prototypic pharmaceutical contaminants target molecular events associated with pharmaceutical-induced gene induction and repression in exposed organisms. Gene expression profiles are subsequently evaluated as a means to discern pharmaceutical exposure. When fully developed, this bioanalytical approach will provide an efficient and robust method for screening pharmaceutical contaminants in reuse and other water matrices.
