A01=Francesco M. Marincola
Affinity IgE Receptor
Age Related Diseases
ATA Haplotype
Author_Francesco M. Marincola
Category=PS
Endogenous IL-10
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High IL-10 Production
HLA B27 Positive Patient
IL-10 Act
IL-10 Effect
IL-10 Function
IL-10 Gene
IL-10 Gene Polymorphism
IL-10 Polymorphism
IL-10 Promoter
IL-10 Promoter Region
IL-10 Promotor Polymorphism
IL-10 Protein Level
IL-10 Therapy
IL-10 Transgenic Mouse
Loop AB
Neuropsychiatric Sle
Proliferating Airway Smooth Muscle Cells
ReA Patient
Recombinant IL-10
Reduce IL-10 Level
SLE Patient
Product details
- ISBN 9781587062858
- Weight: 480g
- Dimensions: 152 x 229mm
- Publication Date: 26 Jan 2006
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Hardback
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Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.
Francesco M. Marincola, Immunogenetic Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, U.S.A.
