Knowledge Discovery in Proteomics

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A01=Dennis Wigle
A01=Igor Jurisica
advanced proteomics data analysis
Author_Dennis Wigle
Author_Igor Jurisica
base
biological network modelling
Category=PBW
Category=PS
computational biology methods
crystallization
Crystallization Experiments
data
data mining bioinformatics
Degree Distribution
DNA Damage Response Pathway
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eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
Genbank Id
high-throughput analysis
HTP Dataset
Interacting Protein Pairs
LC MS Experiment
MALDI ToF MS
management
map
mass
Metabolic Networks
multi-omics data integration
Peptidyl Prolyl Cistrans Isomerase
PIs
Power Law Degree Distribution
PPI Data
PPI Network
protein
Protein Crystallization
Protein Pairs
Protein Protein Interaction Network Analysis
Radon Transform
Random Graph
Ras Guanine Nucleotide Exchange Factor
Real World Networks
Scale Free Network
self-organizing
SH3 Domain
spectrometry
Support Vector Machines
system
systems biology integration
Tandem Mass Spectra

Product details

  • ISBN 9780367392178
  • Weight: 703g
  • Dimensions: 156 x 234mm
  • Publication Date: 23 Oct 2019
  • Publisher: Taylor & Francis Ltd
  • Publication City/Country: GB
  • Product Form: Paperback
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Multi-modal representations, the lack of complete and consistent domain theories, rapid evolution of domain knowledge, high dimensionality, and large amounts of missing information - these are challenges inherent in modern proteomics. As our understanding of protein structure and function becomes ever more complicated, we have reached a point where the actual management of data is a major stumbling block to the interpretation of results from proteomic platforms, to knowledge discovery.

Knowledge Discovery in Proteomics presents timely, authoritative discussions on some of the key issues in high-throughput proteomics, exploring examples that represent some of the major challenges of knowledge discovery in the field. The authors focus on five specific domains:

  • Mass spectrometry-based protein analysis
  • Protein-protein interaction network analysis
  • Systematic high-throughput protein crystallization
  • Systematic, integrated analysis of multiple data repositories
  • Systems biology

    In each area, the authors describe the challenges created by the type of data produced and present potential solutions to the problem of data mining within the domain. They take a systems approach, covering individual data and integrating its computational aspects, from data preprocessing, storage, and access to analysis, visualization, and interpretation.

    With clear exposition, practical examples, and rich illustrations, this book presents an outstanding overview of this emerging field, and builds the background needed for the fruitful exchange of ideas between computational and biological scientists.
  • Jurisica, Igor; Wigle, Dennis

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