A01=Gastone Gilli
A01=Paola Gilli
Author_Gastone Gilli
Author_Paola Gilli
Category=PH
Category=PN
Category=PNT
Category=PSD
Category=PSE
eq_bestseller
eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
Product details
- ISBN 9780199558964
- Weight: 705g
- Dimensions: 163 x 241mm
- Publication Date: 25 Jun 2009
- Publisher: Oxford University Press
- Publication City/Country: GB
- Product Form: Hardback
Secure
checkout
Fast Shipping
Easy returns
Hydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning and presented as an inclusive compilation of experimental H-bond energies and geometries.
New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but inter-consistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond proton-transfer pathway.
Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials.
Gastone Gilli
Full Professor of Physical Chemistry and Director of the Centre for Structural Diffractometry
University of Ferrara, Italy
Dr Paola Gilli
Researcher of Physical Chemistry
University of Ferrara, Italy
