Nmr With Biological Macromolecules In Solution: A Selection Of Papers Published From 1996 To 2020 By Kurt Wuthrich
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G Protein-Coupled Receptors
Mad Cow Disease (TSE)
NMR Techniques for Biological Macromolecules
Nuclear Magnetic Resonance (NMR) Spectroscopy
Prion Proteins
Protein Chaperones
Protein Folding
Protein Structures in Solution
Signal Transfer by Pheromones
Structural Biology
Transmissible Spongiform Encephalopathies (TSEs)
Product details
- ISBN 9789811235788
- Publication Date: 03 Nov 2021
- Publisher: World Scientific Publishing Co Pte Ltd
- Publication City/Country: SG
- Product Form: Hardback
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The book provides insights into the research of the Kurt Wüthrich laboratories from 1996-2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones.Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome , metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones.
