A01=Lynne E. Maquat
Author_Lynne E. Maquat
Category=PS
Decapping Enzyme
Downstream Sequence Element
EJC Component
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eq_isMigrated=1
eq_nobargain
eq_non-fiction
eq_science
Exon Exon Junction
Histone mRNA
mRNA Association
mRNA Decay
NMD Pathway
Nonsense Alleles
Nonsense Mediated mRNA Decay
Nuclear PABP
Pioneer Round
Premature Stop Mutations
Premature Termination Codons
PTCs
Replication Dependent Histone mRNAs
RNA Dependent ATPase
SLBP
SR Protein
Stop Codon
Termination Codon
TR Model
Upf Proteins
Upstream Open Reading Frame
Wild Type mRNA
Product details
- ISBN 9781587062964
- Weight: 408g
- Dimensions: 152 x 229mm
- Publication Date: 28 Feb 2006
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Paperback
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Nonsense-Mediated mRNA Decay is the first book devoted to nonsense-mediated mRNA decay (NMD). The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of post-transcriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cerevisiae and mammals, from which most NMD data derive. Chapters within these sections discuss the two basic ways cells differentiate between a termination codon that elicits NMD and one that does not. Nonsense-Mediated mRNA Decay makes clear that studies of NMD provide a unique opportunity to examine the coupling of mRNA translation and decay, and relationships between mRNP structure and function. The importance of NMD is evident from descriptions of its influence on the expression of genes that are essential for many cellular processes, including cell differentiation, cell maintenance and cell death. This book is, essentially, meant to be a one-stop source of information that fuels the fires of future experimentation.
Lynne E. Maquat Ph.D, is Professor of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry in Rochester, New York. She has studied nonsense-mediated mRNA decay since 1980, beginning with characterizations of patients having the hemolytic anemias ß°-thalassemia and triosephosphate isomerase deficiency. She is currently President of the RNA Society and member of the Public Information Committee of the American Society for Cell Biology.
