A01=Ayman F. El-Kattan
Applications and Methods
Author_Ayman F. El-Kattan
B09=Mike S. Lee
Biopharmaceutics Drug Disposition Classification System (BDDCS)
Category1=Non-Fiction
Category=NL-TC
Category=NL-TD
Category=TCB
Category=TDC
COP=United States
Discount=15
drug discovery and development
drug metabolism
drug permeability
drug solubility
efflux transporters
eq_bestseller
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_tech-engineering
Extended Clearance Classification System (ECCS)
fa
fg
fh
first pass effect
Format=BB
Format_Hardback
HMM=241
IMPN=John Wiley & Sons Inc
in vitro and in vivo ADME assays
ISBN13=9781118916698
Language_English
Oral bioavailability
PA=Available
PD=20170526
pharmacokinetics
physicochemical and biopharmaceutical parameters
POP=New York
preclinical and clinical development
Price_€100 to €200
PS=Active
PUB=John Wiley & Sons Inc
SMM=29
SN=Wiley Series on Pharmaceutical Science and Biotechnology: Practices
Subject=Biochemical Engineering
Subject=Industrial Chemistry & Manufacturing Technologies
uptake transporters
WG=776
WMM=157
Product details
- ISBN 9781118916698
- Format: Hardback
- Weight: 771g
- Dimensions: 158 x 239 x 29mm
- Publication Date: 01 Aug 2017
- Publisher: John Wiley & Sons Inc
- Publication City/Country: New York, US
- Product Form: Hardback
- Language: English
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
AYMAN F. EL-KATTAN, B. Pharm, PhD, is Associate Research Fellow in Pfizer's Pharmacokinetics, Dynamics, and Metabolism Department, Cambridge Laboratories and an Adjunct Professor at College of Pharmacy-University of Rhode Island in Rhode Island, US. Dr. El-Kattan is a reviewer for several journals and is an active member of the American Association of Pharmaceutical Scientists (AAPS). He serves on the executive committee of the Drug Transporter focus group. He has been invited speaker 50 times at national/international conferences and has published over 100 papers in peer-reviewed Journals, book chapters, and proceedings.
