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Origin and Evolution of Telomeres

Jozef Nosek | Lubomir Tomaska
€179.80
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A01=Jozef Nosek
A01=Lubomir Tomaska
Alt Activity
Alt Mechanism
Alt Pathway
Alt Phenotype
Author_Jozef Nosek
Author_Lubomir Tomaska
Break DNA End
Category=PS
DNA End
DNA Substrate
Duplex Telomeric DNA
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Extrachromosomal Circular DNA
Linear DNA
Linear DNA Molecule
MRN Complex
Nontelomeric DNA
PDB Id
SSB Protein
Subtelomeric DNA
T-loop Formation
Telomere DNA Sequence
Telomere End Protection
Telomere Maintenance Mechanisms
Telomere Position Effect
Telomeric DNA
Telomeric Sequences
Telomeric Silencing
TPE

Product details

  • ISBN 9781587063091
  • Weight: 408g
  • Dimensions: 152 x 229mm
  • Publication Date: 26 May 2008
  • Publisher: Taylor & Francis Ltd
  • Publication City/Country: GB
  • Product Form: Hardback
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Description

Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes.
Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller in 1938. Telomeres are specialized structures that comprise the ends of linear chromosomes in eukaryotes. Linearity is crucial for chromosome pairing during meiosis and sexual reproduction.
Inspired by Dobzhansky's dictum that "nothing in biology makes sense except in the light of evolution", this book brings together information about the origin and evolution of telomeres, their functions and the consequences of eukaryotic linearity which is an essential prerequisite of meiotic cell division and sexual reproduction. Selective pressure toward linearization must have been associated with the emergence of robust and redundant mechanisms for the maintenance of telomeres. These pathways comprise a molecular clock involved in cell senescence, carcinogenesis and immortalization.
About Jozef Nosek | Lubomir Tomaska
Jozef Nosek PhD, DSc is an Associate Professor at the Department of Biochemistry, Faculty of Natural Sciences at Comenius University in Bratislava, Slovakia. His research interests include biology and evolution of telomeres, replication of linear mitochondrial genomes and function of their terminal structures, biogenesis of organelles, and morphogenesis of eukaryotic cells. Lubomir Tomaska, PhD, DSc, is an Associate Professor at the Department of Genetics, Faculty of Natural Sciences at Comenius University in Bratislava, Slovakia. He is interested in nucleo-protein structure of nuclear and mitochondrial telomeres, evolutionary pathways leading to different means of telomere maintenance, mitochondrial morphogenesis and inheritance and interplay between the compartments of eukaryotic cells.

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