Path to Effective Recovering of DNA from Formalin-Fixed Biological Samples in Natural History Collections
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A01=Board on Life Sciences
A01=Division on Earth and Life Studies
A01=National Research Council
Author_Board on Life Sciences
Author_Division on Earth and Life Studies
Author_National Research Council
Category=YPMP1
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Product details
- ISBN 9780309102933
- Dimensions: 152 x 229mm
- Publication Date: 26 Sep 2006
- Publisher: National Academies Press
- Publication City/Country: US
- Product Form: Paperback
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Museums catalogue our knowledge of the Earth's biodiversity, and their collections represent many decades of work by experts. Access to DNA sequence information in archival specimens would greatly extend knowledge of the genetic relationships within our biosphere. However, molecular genetic analysis of museum specimens has been slowed by the usual practice of fixation and storage of samples in formalin. Formalin is an environmental toxin and induces genetic and chromosomal alterations to the samples. Few of the many attempts to obtain and sequence DNA from formalin-fixed specimens stored in aqueous formalin or ethanol have been successful. All of the protocols are slow, difficult, and often expensive, and few produce DNA fragments longer than 500 base pairs. Path to Effective Recovering of DNA from Formalin-Fixed Biological Samples in Natural History Collections examines past attempts on DNA recovery from formalin-preserved biological specimens and discusses the research needed to advance the development of similar but more efficient and cost-effective protocols.
Evonne P. Y. Tang, Editor, National Research Council
