A01=Lloyd D. Fricker
Author_Lloyd D. Fricker
bioactive peptide maturation
Category=PSB
cDNA cloning techniques
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eq_isMigrated=1
eq_isMigrated=2
eq_nobargain
eq_non-fiction
eq_science
gene expression control
mammalian proteases
neuroendocrine peptide processing mechanisms
peptide hormone regulation
protein precursor modification
Product details
- ISBN 9780849388521
- Weight: 566g
- Dimensions: 152 x 229mm
- Publication Date: 24 Jul 1991
- Publisher: Taylor & Francis Inc
- Publication City/Country: US
- Product Form: Hardback
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This book provides a comprehensive review of the field of peptide biosynthesis. Individual chapters range from historical perspectives of the field to current knowledge regarding specific enzymes. Every step from gene to final bioactive peptide is covered in detail. Approximately two thirds of the book reviews the enzymes responsible for intracellular and extracellular peptide processing. Other chapters cover issues such as tissue-specific processing and the subcellular sorting of the peptides. New areas covered include the discovery, purification, characterization, and cDNA cloning of peptide processing enzymes involved with endopeptidase processing, carboxypeptidase processing, and C-terminal amidation; identification of the mammalian KEX-2 (subtilisin-like) family of proteases; identification of a second enzyme involved in C-terminal amidation; and the characterization of regulatory elements in neuropeptide genes and the associated DNA-binding proteins, such as CREB and related proteins, in addition to the Pit-1/GHF-1 family of proteins. The book's extensive coverage and 1000 references make it important reading material for new and established researchers in this rapidly expanding field.
