Pharmaceutical Crystals

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A guide to Pharmaceutical Crystals

A01=Alessandra Mattei
A01=Tong Li
Author_Alessandra Mattei
Author_Tong Li
biopharmaceutical development and crystals
Category=MKG
Chemical Stability and Reactivity
chemically-labile molecule
Crystalline Nanoparticles
crystallize in solid forms
Crystallography
downstream processing and long term storage
eq_isMigrated=1
eq_nobargain
impurities during crystallization
Intermolecular Interactions and Computational Methods
macroscopic powder
Measurement and Mathematical Relationships of Cocrystal
Mechanical Properties
microscopic crystals
multi-component crystal forms
Nucleation
organic solids
Polymorphism and Phase Transition
Primary Processing of Organic Crystals
resource for understanding pharmaceutical crystals
review of pharmaceutical crystals
salts hydrates and co-crystals

Secondary Processing of Organic Crystals
substances of scientific technological and commercial importance
text on pharmaceutical crystals
the engineering of pharmaceutical crystals
the science of pharmaceutical crystals
Thermodynamic Properties

Product details

  • ISBN 9781119046295
  • Weight: 862g
  • Dimensions: 152 x 231mm
  • Publication Date: 30 Nov 2018
  • Publisher: John Wiley & Sons Inc
  • Publication City/Country: US
  • Product Form: Hardback
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An important resource that puts the focus on understanding and handling of organic crystals in drug development

Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal.

Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text:

  • Includes the most important aspects of solid-state organic chemistry and its role in drug development
  • Offers solutions for pharmaceutical form selection and crystallization processes
  • Contains a balance between the scientific fundamental and pharmaceutical applications
  • Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability 

Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

TONGLEI LI is Professor in Industrial & Physical Pharmacy at Purdue University, West Lafayette, IN.

ALESSANDRA MATTEI is a Senior Scientist in Solid State Chemistry at AbbVie, North Chicago, IL.

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