Pore-forming Peptides and Protein Toxins
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€291.40
acid
amino
amyloid disease research
antimicrobial peptides
bacterial pathogenesis
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bilayers
Category=PSB
channel
conductance
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eq_nobargain
eq_non-fiction
eq_science
formation
ion channel biophysics
lipid
membrane disruption
membrane-active toxin applications
neurotoxin mechanisms
planar
single
Product details
- ISBN 9780415298520
- Weight: 848g
- Dimensions: 174 x 246mm
- Publication Date: 30 Jan 2003
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Hardback
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Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has led to an abundance of scientific, medical, and commercial applications with unlimited potential.
Pore-forming Peptides and Protein Toxins describes how natural and synthetic peptides and toxins form pores and ionic channels that cause cell membrane collapse and cell death. Divided into two parts on pore-forming proteins and pore-forming peptides, each chapter reviews the normal physiological cellular structure and function, discusses the interference of toxins with this process, and considers the use of specific toxins in research. Written by researchers from around the world, the text includes such topics as the channel-forming properties of Helicobacter pylori and the role of amyloid peptide channels in the development of amyloid diseases.
This authoritative volume provides a multidisciplinary approach to understanding the basic principles and cellular mechanisms of the action of toxins and their potential use as research tools. It is an essential work for researchers and students in the fields of biochemistry, toxicology, biophysics, and pharmaceutical science.
Gianfranco Menestrina, M. Dalla Sera
