A01=. Yury O. Chernoff
amyloid formation
Author_. Yury O. Chernoff
Category=PS
Category=PSAK
Category=PSD
cellular memory mechanisms
Centriole Assembly
Centriole Duplication
Cytoplasmic Incompatibility
epigenetic inheritance
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eq_isMigrated=0
eq_isMigrated=1
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genetic regulation in fungi
Heat Shock
Heterologous Prion
molecular chaperones
Nonsense Allele
OPR
Pericentriolar Matrix
Podospora Anserina
PrD
Prion Aggregates
Prion Dom Ain
Prion Form
Prion Polymers
Prion Properties
Prion Proteins
Prion Seeds
Prion State
Prion Variants
protein folding disorders
PrP
Small Heat Shock Protein Hsp26
Spindle Assembly Checkpoint
Sup35 Prion Domain
template-based trait transmission
TSE Strain
Yeast Prions
Product details
- ISBN 9781587061387
- Weight: 340g
- Dimensions: 152 x 229mm
- Publication Date: 04 Sep 2007
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Hardback
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This book covers a topic that has been neglected for years and has returned to the spotlight only recently. Until the genetic role of DNA was firmly established, many researchers suspected that proteins, rather than nucleic acids, could be carriers of heritable information. However, these models were completely forgotten with the triumphal march of the double helix and the development of a central dogma postulating that information flow occurs strictly from DNA, through RNA, to protein, making it seemingly impossible for the proteins to possess a coding potential. Proteins were downgraded to the role of simple perpetuators and executors of DNA orders. Taken together, data included in this book prove beyond a reasonable doubt that proteins and multiprotein complexes are able to control heritable traits, and that, at least in some examples, this control occurs in a template-like fashion, so that new structures strictly reproduce patterns of pre-existing structures that were not specifically coded in DNA. Thus, protein-based inheritance has left the area of speculation and has emerged as a new topic amenable to high-quality experimental analysis.
