Protein-protein Complexes: Analysis, Modeling And Drug Design
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Protein Design
Protein Evolution
Protein Interaction Network
Protein-Protein Complexes
Protein-Protein Interactions
ProteinAcAEURA"Protein Complexes
ProteinAcAEURA"Protein Interactions
Protein–Protein Complexes
Protein–Protein Interactions
Structural Bioinformatics
Product details
- ISBN 9781848163386
- Publication Date: 10 May 2010
- Publisher: Imperial College Press
- Publication City/Country: GB
- Product Form: Hardback
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Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
