Aminopeptidases
biochemical assay techniques
Calpain
Category=PNB
Category=PSB
Cathepsins
cytomegalovirus proteinase
Enzyme classes and mechanisms
enzyme regulation pathways
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Herpes virus
HIV
Human rhinovirus
Matrix metalloproteinases
molecular pharmacology research
protease inhibition mechanisms
Proteasomes
proteinase inhibitor drug development
Protozoan parasites
serine protease inhibitors
therapeutic target identification
Thrombin
Tumor therapy
uPA
Zinc metallopeptidases
Product details
- ISBN 9780367454982
- Weight: 453g
- Dimensions: 178 x 254mm
- Publication Date: 02 Dec 2019
- Publisher: Taylor & Francis Ltd
- Publication City/Country: GB
- Product Form: Paperback
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Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the treatment of various disorders. Proteinase and Peptidase Inhibition presents updated progress reports on the characterization of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. Introductory chapters deal with the broad enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understanding how inhibition of different targets can lead to the same therapeutic outcomes. This is a valuable reference book that will appeal to both academic and industrial researchers in the fields of medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.
Smith, H. John; Simons, Claire
