A01=John N. Prebble
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Author_John N. Prebble
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Product details
- ISBN 9780190866143
- Weight: 635g
- Dimensions: 157 x 236mm
- Publication Date: 31 Jan 2019
- Publisher: Oxford University Press Inc
- Publication City/Country: US
- Product Form: Hardback
- Language: English
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Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "bioenergetics revolution" has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced into the field until Albert Szent-Gyorgyi published a small book under that title in 1957.
Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies.
John N. Prebble is an Honorary Fellow of Royal Holloway, University of London and Emeritus Senior Lecturer in Biochemistry in the School of Biological Sciences.
