Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
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assembly
carbohydrate
carbohydrates
Category=PNN
challenges
combinatorial
coverage
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eq_nobargain
eq_non-fiction
eq_science
expectation
field
libraries
oligosaccharide
oligosaccharides
presents
recent developments
solid
solidphase
synthesis
thorough
unique
Product details
- ISBN 9780471378280
- Weight: 583g
- Dimensions: 162 x 246mm
- Publication Date: 21 Aug 2001
- Publisher: John Wiley & Sons Inc
- Publication City/Country: US
- Product Form: Hardback
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Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:
- Specific oligosaccharide structures used in signal transduction processes
- Preparation and screening of glycopeptide libraries
- Solid-phase carbohydrate synthesis
PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.
