Toxicology of 1 - 3-Beta-Glucans

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13C NMR Spectrum
albicans
BAL Fluid
biological
Blood Concentrations
candida
Candida Cells
Category=PSB
cell
deep
Deep Mycoses
environmental mycology
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eq_nobargain
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Field Study
fungal cell wall analysis
Glucan Polymer
Glucan Receptors
helix
ICR Mouse
immunotoxicology
indoor air quality fungal contamination
Inflammatory Potency
LAL Assay
Limulus Amebocyte Lysate Test
Limulus Test
LPS Exposure
Lu Ca
MAPK Cascade
MRL Lpr
mycoses
NaOH Treatment
OA Specific IgE
occupational exposure assessment
PLN Assay
pulmonary inflammation research
response
Serum OA Specific IgE
signal transduction pathways
SPG
Surfactant Protein
Test Mk
Total IgE Level
triple
wall

Product details

  • ISBN 9780415700375
  • Weight: 476g
  • Dimensions: 156 x 234mm
  • Publication Date: 18 Mar 2005
  • Publisher: Taylor & Francis Ltd
  • Publication City/Country: GB
  • Product Form: Hardback
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The investigation of indoor air quality has shown that microbial contamination is often a problem in buildings. Recent evidence indicates that fungi are often a part of the picture. A component of the fungal cell wall, 1®3-ß-glucans not only affect human health, they are a marker for the existence of fungi in environmental samples. Toxicology of 1®3-ß-Glucans covers the basic chemistry and immunobiology of these substances. The authors begin by introducing current methods for detecting 1®3-ß-glucans in environmental samples and reviewing risk evaluation in the environment. They go on to discuss numerous topics including likely occupational and environmental exposure, studies suggesting a strong link between environmental glucan concentrations and pulmonary inflammation, and signal transduction pathways and specific receptors. No other book currently available brings together the expertise of leading international researchers to provide a straightforward monograph on the toxicology of 1®3-ß-glucans. It pulls together current knowledge of these compounds, their effects, measurement, monitoring, and risk assessment.
Shih-Houng Young, Ph.D., received a B.S. and an M.S. in chemistry from National Tsing Hua University, Hsinchu, Taiwan. After eight years of working in the field of occupational safety and health, he decided to further his education in occupational health. He went to University of Alabama at Birmingham and received a Ph.D. in environmental health sciences and industrial hygiene in 1998. He is a member of the American Industrial Hygiene Association and the American Conference of Governmental Industrial Hygienists. His thesis involved the elucidation of conformational-biological activity relationships of (1?3)-?-glucans via the fluorescence resonance energy transfer method. He was awarded a National Research Council Associateship at the National Institute for Occupational Safety and Health (NIOSH) to continue his study in (1?3)-?-glucans. Vincent Castranova, Ph.D., is the Chief of the Pathology and Physiology Research Branch in the Health Effects Laboratory Division of the National Institute for Occupational Safety and Health, Morgantown, WV. He holds the grade of a CDC Distinguished Consultant. He is also an adjunct professor in the Department of Physiology and the Department of Basic Pharmaceutical Sciences at West Virginia University, Morgantown, WV and the Department of Environmental and Occupational Health at the University of Pittsburgh, Pittsburgh, PA. He is a member of the American Physiological Society, the Society of Toxicology, Beta Beta Beta, and the Allegheny-Eric Chapter of the Society of Toxicology, where he once served as president. He is on the editorial board of Annals of Agricultural and Environmental Medicine, the Journal of Toxicology and Environmental Health, and Toxicology and Applied Pharmacology. In addition, he was guest editor for the Journal of Environmental Pathology, Toxicology and Oncology.