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B01=Amine Kamen
B01=Laura Cervera
Category1=Non-Fiction
Category=MJCM
Category=MQW
Category=PS
Category=TCB
Category=TDCB
Category=TQ
COP=United Kingdom
Delivery_Pre-order
Language_English
PA=Not yet available
Price_€50 to €100
PS=Forthcoming
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Bioprocessing of Viral Vaccines

English

This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.

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Current price €54.14
Original price €56.99
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Age Group_Uncategorizedautomatic-updateB01=Amine KamenB01=Laura CerveraCategory1=Non-FictionCategory=MJCMCategory=MQWCategory=PSCategory=TCBCategory=TDCBCategory=TQCOP=United KingdomDelivery_Pre-orderLanguage_EnglishPA=Not yet availablePrice_€50 to €100PS=Forthcomingsoftlaunch

Will deliver when available. Publication date 29 Jul 2024

Product Details
  • Weight: 610g
  • Dimensions: 156 x 234mm
  • Publication Date: 29 Jul 2024
  • Publisher: Taylor & Francis Ltd
  • Publication City/Country: United Kingdom
  • Language: English
  • ISBN13: 9781032135519

About

Amine Kamen is a professor of bioengineering at McGill University and CanadaResearch Chair in bioprocessing of viral vaccines. He is a researcher emeritus of theNational Research Council of Canada (NRC) where he was employed until early2014 as head of the Process Development section of the Human Health TherapeuticsPortfolio. At NRC he established one of North Americas largest and most advancedgovernmental centers for animal cell culture addressing process development andscale-up of biologics. Also he developed with his team and licensed to industrymultiple technology platforms for efficient manufacturing of recombinant proteinsand viral vectors and vaccines and led technology transfer to manufacturing sites forclinical evaluation and commercialization. His current research activities focus onuncovering mechanisms associated with cell production of viral vectors and viralvaccines cell and metabolic engineering process control and monitoring and processanalytical technologies of high-yield productions of viral vectors for gene deliveryand vaccination. He has published over 170 papers in refereed international journalsand acts as a consultant for several national and international private and publicorganizations.Laura Cervera is a Chemical Engineer from Universitat Autònoma de Barcelona(Barcelona Spain). After graduating she did her PhD in Biotechnology on the topicStrategies for improving production levels of HIV-1 VLPs by transient transfectionof HEK 293 suspension cultures. Then she moved to McGillUniversity (MontrealCanada) to pursue her research on VLP production this time using Insect cells as aplatform. She came back to Barcelona to join a project on AAV production for genetherapy applications using HEK 293 cells.

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