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B01=Eric Mcdade
B01=Jasmeer Chhatwal
Category1=Non-Fiction
Category=JMM
Category=JPSL
Category=PSAN
COP=United Kingdom
Delivery_Pre-order
Language_English
PA=Not yet available
Price_€100 and above
PS=Forthcoming
softlaunch

Autosomal Dominant Alzheimer''s Disease: A Pathophysiology Review

★★★★★
★★★★★

English

Biomarkers play an indispensable role in Alzheimer's Disease (AD) diagnosis, clinical research and clinical trials. Our understanding of AD biomarkers has been profoundly impacted by the study of Autosomal Dominant Alzheimer's Disease (ADAD). Though memory loss is the most common feature of ADAD, motor dysfunction, neuropsychiatric symptoms, and epileptiform abnormalities are present at a much higher rate in ADAD than sporadic, late-onset AD. There are over 250 known ADAD-causative variants in PSEN1, 2, and APP. This genetic heterogeneity is reflective in both biomarkers and cognitive heterogeneity across people with ADAD. Autosomal Dominant Alzheimer's Disease: A Pathophysiology Review discusses the history of ADAD and its cognitive, neuroimaging and biomarker trajectories. This book focuses how ADAD can provide a unique insight into genetically driven and sporadic forms of AD. Edited by Dr. Jasmeer Chhatwal and Dr. Eric McDade, and contributed by leading experts in the field, this book will be become the leading tool for researchers and clinicians in Alzheimer's Disease. See more
€118.67
€128.99
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Age Group_Uncategorizedautomatic-updateB01=Eric McdadeB01=Jasmeer ChhatwalCategory1=Non-FictionCategory=JMMCategory=JPSLCategory=PSANCOP=United KingdomDelivery_Pre-orderLanguage_EnglishPA=Not yet availablePrice_€100 and abovePS=Forthcomingsoftlaunch

Will deliver when available. Publication date 01 Sep 2024

Product Details
  • Dimensions: 151 x 229mm
  • Publication Date: 01 Sep 2024
  • Publisher: Elsevier Science & Technology
  • Publication City/Country: United Kingdom
  • Language: English
  • ISBN13: 9780323997164

About

Jasmeer Chhatwal MD PhD MMSc Assistant Professor of Neurology Harvard Medical School; Associate Neurologist Massachusetts General Hospital. Dr. Chhatwal is a neurologist and translational neuroscientist at Harvard Medical School who uses a diverse array of genetic neuroimaging and biochemical tools to study Alzheimers disease. He serves as a site leader for the Dominantly Inherited Alzheimers Network (DIAN) a project leader for the Harvard Aging Brain Study and leads studies examining potentially modifiable risk factors for cognitive decline in older adults. Clinically he sees a wide variety of patients with cognitive disorders with a particular focus on early onset Alzheimer's disease (AD). Eric McDade DO Associate Professor of Neurology Washington University School of Medicine at St. Louis. Dr. McDade is a Neurologist with a specialty in Cognitive Neurology. He is the Associate Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and the Clinical Core lead of the Dominantly Inherited Alzheimer Network. Dr. McDades clinical research focuses on fluid and imaging biomarkers in preclinical Alzheimer disease and their application in the development of Alzheimer prevention clinical trials. He leads the DIAN-TU Primary Prevention Trial.

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