Sydney Brenner''s 10-on-10: The Chronicles Of Evolution

About

Sydney Brenner was born in 1927 in South Africa where he attended high school and medical school; he later received his DPhil from Oxford University UK. One of the pioneers of modern molecular biology Brenner was instrumental in deciphering the basic principles of the genetic code. In the 1960s together with Francis Crick Brenner showed that the code is composed of non-overlapping triplets; in collaboration with Francois Jacob and Matthew Meselson he went on to demonstrate the existence of messenger RNA. Brenner is also known for spearheading the use of the nematode worm Caenorhabitis elegans as a model organism for understanding human biology. He was later awarded the 2002 Nobel Prize in Physiology or Medicine (with H. Robert Horvitz and John E. Sulston) for his work in C. elegans on the genetics of programmed cell death. In the genomic era Brenner developed new methods for next generation DNA sequencing and initiated a project to sequence the compact genome of the Japanese pufferfish or fugu. Brenner is currently scientific advisor to the chairman at the Agency of Science Technology and Research (A*STAR) Singapore and an adjunct professor at the Lee Kong Chian School of Medicine Nanyang Technology University Singapore among other affiliations. He continues to work on genomes and their evolution.