Antimalarial Drug Research & Development

Malaria-like febrile illnesses have been described since Hippocrates as fevers that were periodic and associated with marshes and swamps. The word malaria comes from the Italian mal''aria for bad airs . Malaria is transmitted to humans via the bite of the infected female mosquito of anopheles species. Malaria can exist, in a mild form that is most commonly associated with flu-like symptoms; fever, vomiting, and general malaise. Most disease cases are found in the poorest countries; tropical Africa, Latin America, Southern Asia and Oceania. More concern is being given now to malaria even in countries where there is a low risk of infection due to the phenomena of global warming which is significantly increasing. In this book, the authors present current research in the study of anti-malarial drug research and developments. Topics discussed in this compilation include the anti-malarial atovaquone prodrugs based on enzyme models with molecular orbital calculations approach; new quinoline-based multiple ligands in antimalarial drug development; new molecular scaffolds as potential therapeutic agents to combat antimalarial resistance; and PfCRT mediates sensitivity of chloroquine-resistant P Falciparum to diamidines. See more