Glycoconjugates of the Pancreas

About

Kenichi Hakamada graduated from Hirosaki University School of Medicine and received his medical license in 1985. His first one-year residency program was at Nakadori General Hospital in Akita Prefecture followed by a two-year residency in Okinawa at Okinawa Prefectural Chubu Hospital. Since May 1988 he has been back at his alma mater initially working as a hepatopancreatobiliary surgeon at Hirosaki University Hospital Department of Surgery II. In 2001 he joined the faculty as a lecturer and in 2005 he became an associate professor. In August 2008 he became a full professor in charge of the Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine. He has conducted many research projects primarily in the area of living-donor liver transplantation. He has also worked on cutting-edge studies on the application of 4-methylumbelliferon (4-MU) to human pancreatic cancer. In April 2023 he was appointed Director of Hirosaki University Hospital.   Keinosuke Ishido graduated from Hirosaki University School of Medicine and recieved his medical license in 1998. He received his PhD in 2002. At the Hirosaki University Graduate School of Medicine he has conducted extensive research on the glycosyl transfer reaction of endo-b-xylosidase.  He developed a novel method of synthesizing neoproteglycan using the glycosyl transfer reaction of endo-b-xylosidase. He succeeded in transferring a whole glycosaminoglycan chain to a peptide using this method which was the first time such an accomplishment was ever reported. Since 2008 he has worked in the Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine as a hepatobiliary-pancreatic surgeon. In 2012 he joined the universitys faculty as a lecturer and in 2016 he was promoted to associate professor. Professor Ishido currently specializes in the surgical treatment of hepatobiliary and pancreatic diseases. Daisuke Kudo graduated from Hirosaki University School of Medicine and recieved his medical license in 1999. He received his PhD in 2003. At Hirosaki University Graduate School of Medicine his research has focused on the inhibitory effects of hyaluronic acid synthesis by 4-methylumbelliferon (4-MU). He was the first in the world to report effectively blocking melanoma metastasis by inhibiting hyaluronic acid synthesis with 4-MU. In 2009 he began work in the Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine as a hepatobiliary-pancreatic surgeon. In 2013 he joined the faculty as a lecturer and in 2019 he became an associate professor. Since 2019 he has specialized in the surgical treatment of hepatobiliary and pancreatic and gastrointestinal diseases at Tsugaru General Hospital. He currently serves as the director of the Gastroenterology Center of the hospital.   Eri Yoshida graduated from Hirosaki University School of Medicine and recieved her medical license in 2009. She received her PhD in 2016. At Hirosaki University Graduate School of Medicine her research has focused on the inhibitory effects of hyaluronic acid synthesis by 4-methylumbelliferon (4-MU). She was the first in the world to report 4-MU decreases the biological barrier effect of hyaluronan-rich extracellular matrix and increases the effectiveness of 5-Fluorouracil. In 2017 she began work in the Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine as an upper gastrointestinal tract surgeon.