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B01=Corinne M. Spickett
B01=Henry Jay Forman
Category1=Non-Fiction
Category=MJG
Category=PSBH
Category=PSD
Category=PSF
COP=United States
Delivery_Pre-order
Language_English
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Lipid Oxidation in Health and Disease

English

Oxidative modification of lipids and phospholipidsincluding radical damage, halogenation, and nitrationresult in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

Covering the diverse topics that contribute to research in this important field, this book explores:

  • The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
  • Antioxidant defenses and lipid oxidation
  • Lipid oxidation products and cell signaling
  • The roles of oxidized lipids in specific diseasesincluding cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
  • Drug targeting and the therapeutic potential of oxidized lipids

Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

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Current price €189.04
Original price €198.99
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Age Group_Uncategorizedautomatic-updateB01=Corinne M. SpickettB01=Henry Jay FormanCategory1=Non-FictionCategory=MJGCategory=PSBHCategory=PSDCategory=PSFCOP=United StatesDelivery_Pre-orderLanguage_EnglishPA=Temporarily unavailablePrice_€100 and abovePS=Activesoftlaunch

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Product Details
  • Weight: 772g
  • Dimensions: 152 x 229mm
  • Publication Date: 03 Mar 2015
  • Publisher: Taylor & Francis Inc
  • Publication City/Country: United States
  • Language: English
  • ISBN13: 9781482202854

About

Corinne M. Spickett is a reader at Aston University in Birmingham UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation and has been developing label-free semi-targeted approaches to their identification in biological samples.Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production redox signaling and mechanisms of induced resistance to oxidative stress.

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